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  • Title: [Possible role of transforming growth factor alpha on the cholesteatoma growth regulation].
    Author: Xu Y, Wu Z, Tao Z, Hua Q, Jin K.
    Journal: Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2003 Jan; 17(1):32-4. PubMed ID: 12725186.
    Abstract:
    OBJECTIVE: To investigate the mode of expression and distribution of transforming growth factor alpha in middle ear cholesteatoma. METHOD: The specimens from the cholesteatoma tissue of 32 cases and the normal external ear skin of 10 cases were examined by immunohistochemical S-P method and computer image analysis. RESULT: In cholesteatoma epithelium staining for TGF alpha was consistently stronger than that in normal epithelium. The mean absorbance of the two epithelial tissue is 2.431 +/- 0.587 and 1.463 +/- 0.147 respectively, revealing a significant difference. Some immune cells infiltrating the stroma of cholesteatoma also stained positively for TGF alpha. CONCLUSION: These data suggested that an autocrine and paracrine stimulation of the squamous epithelium of cholesteatoma by TGF might contribute to its hyperproliferation.
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