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  • Title: Protease activated receptors 1 and 4 govern the responses of human platelets to thrombin.
    Author: Ofosu FA.
    Journal: Transfus Apher Sci; 2003 Jun; 28(3):265-8. PubMed ID: 12725953.
    Abstract:
    Studies carried out in the past 12 years have established that activation of protease-activated receptor (PAR)-1 and PAR-4 by thrombin essentially drives human platelet activation. Thrombin is the most potent physiologic agonist of platelets. PAR-1 and PAR-4 are found on human platelets and are half of the family of the four known 7-transmembrane receptors that are activated by a single proteolytic cleavage within the amino terminal extracellular domain of these receptors. This review will consider the direct and indirect evidence that apparently support the idea that PAR-1 and PAR-4 activation by thrombin drives platelet activation
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