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  • Title: Studies on the immunomodulatory activity of flavonoidal fraction of Tephrosia purpurea.
    Author: Damre AS, Gokhale AB, Phadke AS, Kulkarni KR, Saraf MN.
    Journal: Fitoterapia; 2003 Apr; 74(3):257-61. PubMed ID: 12727490.
    Abstract:
    The flavonoid fraction of Tephrosia purpurea (FFTP) was studied for its effect on cellular and humoral functions and on macrophage phagocytosis in mice. Oral administration of FFTP (10-40 mg/kg) significantly inhibited sheep red blood cells (SRBC)-induced delayed-type hypersensitivity reactions. It also produced a significant, dose-related decrease in sheep erythrocyte-specific haemagglutination antibody titre. However, the fraction failed to show a significant change in the macrophage phagocytic activity. The results obtained indicate the ability of the flavonoidal fraction of T. purpurea to modulate both the cell-mediated and the humoral components of the immune system.
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