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  • Title: Synthesis and anti-inflammatory activity of 5-(6-methyl-2-substituted 4-pyrimidinyloxymethyl)-1,3,4-oxadiazole-2-thiones and their 3-morpholinomethyl derivatives.
    Author: Jakubkiene V, Burbuliene MM, Mekuskiene G, Udrenaite E, Gaidelis P, Vainilavicius P.
    Journal: Farmaco; 2003 Apr; 58(4):323-8. PubMed ID: 12727542.
    Abstract:
    The synthesis of 5-(6-methyl-2-substituted 4-pyrimidinyloxymethyl)-2,3-dihydro-1,3,4-oxadiazole-2-thiones and their 3-morpholinomethyl derivatives and the results of anti-inflammatory activity in vivo are described. Most of the tested compounds exhibited anti-inflammatory activity and some of them were more active than acetylsalicylic acid.
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