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  • Title: Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus.
    Author: Lu Z, Raghavan S, Bohn J, Charest M, Stahlhut MW, Rutkowski CA, Simcoe AL, Olsen DB, Schleif WA, Carella A, Gabryelski L, Jin L, Lin JH, Emini E, Chapman K, Tata JR.
    Journal: Bioorg Med Chem Lett; 2003 May 19; 13(10):1821-4. PubMed ID: 12729673.
    Abstract:
    A series of highly potent HIV protease inhibitors have been designed and synthesized. These compounds are active against various clinical viral isolates as well as wild-type virus. The synthesis and biological activity of these HIV protease inhibitors are discussed.
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