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  • Title: Platelets and antiplatelet therapy in patients with diabetes mellitus.
    Author: Arjomand H, Roukoz B, Surabhi SK, Cohen M.
    Journal: J Invasive Cardiol; 2003 May; 15(5):264-9. PubMed ID: 12730635.
    Abstract:
    Atherosclerotic heart disease is the leading cause of death in patients with diabetes mellitus. Platelets play a major role in the clinical manifestations of ischemic heart disease. Diabetic patients have hyperreactive platelets with exaggerated adhesion, aggregation and thrombin generation. Antiplatelet agents, including aspirin, clopidogrel, and glycoprotein IIb/IIIa inhibitors, have shown significant efficacy in reducing recurrent ischemic events in patients with diabetes. Treatment with glycoprotein IIb/IIIa inhibitors during percutaneous coronary intervention reduces mortality in diabetic patients.
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