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  • Title: Effects of hemodynamic overload on canine myocardial myosin.
    Author: Wikman-Coffelt J, McPherson J, Fenner C, Lotysh M, Zelis R, Mason DT.
    Journal: Recent Adv Stud Cardiac Struct Metab; 1975; 5():253-61. PubMed ID: 127355.
    Abstract:
    After mild banding of pulmonary artery in dogs there was a rapid elevation in protein and RNA synthesis, followed by an elevation in myosin content and myosin ATPase activity. There was an increase in myosin ATPase activity when K+ or Ca++ was used as activator effector but not with the cations, Mn++ or NH4+. Concomitant with an increase in myosin ATPase activity there was a decrease in one of the C1 light chain components, previously named C1d.
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