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  • Title: Highly satisfactory alkynylation of alkenyl halides via Pd-catalyzed cross-coupling with alkynylzincs and its critical comparison with the sonogashira alkynylation.
    Author: Negishi E, Qian M, Zeng F, Anastasia L, Babinski D.
    Journal: Org Lett; 2003 May 15; 5(10):1597-600. PubMed ID: 12735730.
    Abstract:
    [reaction: see text] The Pd-catalyzed alkynylation of various alkenyl halides and triflates with alkynylzincs proceeds well even with alkynyl derivatives containing electron-withdrawing groups. The reaction appears to be highly general. Noteworthy is that the corresponding Sonogashira reactions under various reported conditions are significantly less satisfactory in all cases performed in this study.
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