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  • Title: Ingestion of Streptococcus mutans induces secretory immunoglobulin A and caries immunity.
    Author: Michalek SM, McGhee JR, Mestecky J, Arnold RR, Bozzo L.
    Journal: Science; 1976 Jun 18; 192(4245):1238-40. PubMed ID: 1273589.
    Abstract:
    Ingestion of killed cells of a highly cariogenic strain of Streptococcus mutans induced specific antibodies in both saliva and milk but not in serum of gnotobiotic rats. These antibodies were associated with the immunoglobulin A class. When infected with Streptococcus mutans, orally immunized animals developed significantly fewer carious lesions than nonimmunized infected controls.
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