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  • Title: Syntheses, in vitro and in vivo characterization of a 99mTc-(I)-tricarbonyl-benzylamino-dihydroxymethyl phosphine (NP(2)) chelate.
    Author: Kothari KK, Raghuraman K, Pillarsetty NK, Hoffman TJ, Owen NK, Katti KV, Volkert WA.
    Journal: Appl Radiat Isot; 2003 May; 58(5):543-9. PubMed ID: 12735970.
    Abstract:
    Studies were performed to study the complexation chemistry of 99mTc(CO)(+)(3) with a new tridentate amino-dihydroxymethyl phosphine (NP(2)) ligand with the 99mTc(CO)(3)(OH(2))(+)(3) synthon at tracer levels. A single, well-defined 99mTc(CO)(3)NP(2) complex is formed at pH 7.5 within 10 min at 60 degrees C that exhibits high in vitro and in vivo stability.
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