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  • Title: Long-term levodopa therapy for torsion dystonia.
    Author: Still CN, Herberg KP.
    Journal: South Med J; 1976 May; 69(5):564-6. PubMed ID: 1273612.
    Abstract:
    Observation of a 34-year-old woman receiving levodopa for familial torsion dystonia over a four-year period revealed that severe side effects (gastrointestinal problems, dyskinesias, cramps, anxiety) occurred with maximal dosage schedules during the first ten months of treatment. Thereafter, a gradual reduction of the daily dose to 1,500 mg of levodopa gave excellent relief of hypokinesia and rigidity with minimal adverse effects, including abolition of mild akinesia paradoxica which developed after 2 1/2 years of treatment.
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