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  • Title: A patient with Crimean-Congo hemorrhagic fever serologically diagnosed by recombinant nucleoprotein-based antibody detection systems.
    Author: Tang Q, Saijo M, Zhang Y, Asiguma M, Tianshu D, Han L, Shimayi B, Maeda A, Kurane I, Morikawa S.
    Journal: Clin Diagn Lab Immunol; 2003 May; 10(3):489-91. PubMed ID: 12738657.
    Abstract:
    We treated a male patient with Crimean-Congo hemorrhagic fever (CCHF). The diagnosis of CCHF was confirmed by reverse transcription-PCR and recombinant nucleoprotein (rNP)-based immunoglobulin G (IgG) and IgM capture enzyme-linked immunosorbent assays of serially collected serum samples. The patient was treated with intravenous ribavirin and recovered with no consequences. The study indicates that rNP-based CCHF virus antibody detection systems are useful for confirming CCHF virus infections. This case also suggests that intravenous ribavirin therapy may be promising for the treatment of CCHF patients.
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