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Title: Pharmacokinetics of mycophenolic acid associated with calcineurin inhibitors: long-term monitoring in stable lung recipients with and without cystic fibrosis. Author: Gerbase MW, Fathi M, Spiliopoulos A, Rochat T, Nicod LP. Journal: J Heart Lung Transplant; 2003 May; 22(5):587-90. PubMed ID: 12742423. Abstract: Pharmacologic interactions and absorption disturbances after transplantation may induce serologic fluctuation of immunosuppression and adversely affect outcome. We present data showing that trough levels of mycophenolic acid decreased by 50% during combined mycophenolate mofetil (MMF) and cyclosporine therapy compared with levels during combined MMF and tacrolimus therapy. In addition, cystic fibrosis patients required 30% higher doses of MMF to achieve the therapeutic levels of recipients without cystic fibrosis.[Abstract] [Full Text] [Related] [New Search]