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  • Title: A general framework for neurobiological modeling: an application to the vestibular system.
    Author: Eliasmith C, Westover MB, Anderson CH.
    Journal: Neurocomputing (Amst); 2002 Jun; 44-46():1071-6. PubMed ID: 12744262.
    Abstract:
    The otolith organs in the vestibular system are excellent detectors of linear accelerations. However, any measurement of linear acceleration is ambiguous between a tilt in a gravitational field and an inertial acceleration. Angelaki et al. have put forward a general hypothesis about how inertial accelerations can be computed based on vestibular signals (J. Neurosci. 19 (1999) 316). We have constructed a realistic, detailed model of the relevant systems to test this hypothesis. The model produces useful predictions about what kinds of neurons should be found in the vestibular nucleus if such a computation is actually performed in the vestibular system. The model is constructed using general principles of neurobiological simulation (J. Neurophys. 84 (2000) 2113).
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