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  • Title: Clopidogrel-induced systemic inflammatory response syndrome.
    Author: Wolf I, Mouallem M, Rath S, Farfel Z.
    Journal: Mayo Clin Proc; 2003 May; 78(5):618-20. PubMed ID: 12744550.
    Abstract:
    Clopidogrel bisulfate, a widely used inhibitor of platelet aggregation, is considered at least as safe as aspirin. We describe a patient who developed a systemic inflammatory response syndrome consisting of high fever, tachycardia, cellulitis-like rash, impaired liver function, and mild leukopenia after receiving clopidogrel before coronary angiography and stent implantation. The reaction resolved promptly after withdrawal of the drug and recurred shortly after a rechallenge dose was administered, thus making the diagnosis of a clopidogrel-induced reaction highly probable. Recognition of this clopidogrel-induced syndrome is extremely important, both for rapid discontinuation of the offending drug and for avoidance of unnecessary drug therapy or invasive procedures.
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