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  • Title: [Progress and stagnation in chemotherapy protocols for primary osteosarcoma].
    Author: Delépine N, Alkallaf S, Cornille H, Markowska B, Delépine G.
    Journal: Ann Med Interne (Paris); 2003 Feb; 154(1):12-24. PubMed ID: 12746655.
    Abstract:
    Thirty years ago, osteosarcoma of a limb meant amputation and death. Two years after diagnosis, 80% of the patients died from pulmonary metastases, despite early amputation. In 2002, more than 70% of these patients can be cured. Successful cure requires adequate and early management centered on en-bloc resection by a specialized surgeon, followed by a long, expensive, and adapted chemotherapy. The cornerstone is high-dose methotrexate. We present data accumulated over the last 30 years on the treatment of osteosarcoma and point out the fundamental steps of this success story.
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