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  • Title: [Histocompatibility-antigens in hay fever (author's transl)].
    Author: Schunter F, Schieferstein G, Tchorz P, Fischer H, Schneider W.
    Journal: Z Immunitatsforsch Exp Klin Immunol; 1975 Sep; 150(2):105-13. PubMed ID: 127468.
    Abstract:
    HL-A antigens have been determined in 110 not related Caucasian patients from southwest Germany suffering from hay fever and in 353 blood donors from the same area. Gene-frequencies and haplotype-frequencies of these 2 groups were compared, deviations within various specific allergy groups were investigated taking into consideration associated diseases. Patients suffering from hay fever showed a significant increase in frequency of W 19 and a significant decrease in HL-A8. Increase of W 19 was most evident in persons who became sick before the 16th year of age and in those who showed asthmatic symptoms in addition to those of hay fever. HL-A8 is significantly decreased only in persons who became sick after the 16th year of age. Found differences in haplotype-frequencies need further confirmation in larger studies. A relationship between changes of HL-A frequencies in hay fever due to special pollen allergies could not be determined.
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