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  • Title: Biologic activity of soluble collagen-anticollagen immune complexes as demonstrated by passive cutaneous anaphylaxis.
    Author: Menzel J, Steffen C.
    Journal: Z Immunitatsforsch Exp Klin Immunol; 1975 Sep; 150(2):114-23. PubMed ID: 127469.
    Abstract:
    Collagen-anticollagen immune complexes were prepared by gel filtration. Complex formation was chemically and serologically demonstrated. Complexes eluting in gammaM- and gammaG-peaks of antigen-antiserum mixture showed strong positive reactions in PCA experiments performed with 20 guinea pigs. Control preparations of gammaM- and gammaG-peaks of antiserum devoid of antigen gave significantly lower PCA-response. The positive reaction of control preparations can be explained in part by a certain degree of cross-reactivity of anticollagen-antibodies with guinea pig collagen.
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