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  • Title: Elevated serum interleukin 6 levels in patients with acute intestinal ischemia.
    Author: Sutherland F, Cunningham H, Pontikes L, Parsons L, Klassen J.
    Journal: Hepatogastroenterology; 2003; 50(50):419-21. PubMed ID: 12749237.
    Abstract:
    BACKGROUND/AIMS: Early diagnosis of patients with acute intestinal ischemia may be possible by measuring serum cytokine levels. METHODOLOGY: Forty-six patients presenting in emergency with an acute abdomen where intestinal ischemia was a possible diagnosis were evaluated. A single blood sample was collected in emergency prior to any intervention and the patients were then followed prospectively. Serum tumor necrosis factor-alpha and interleukin-6 levels were determined at a later date. Serum levels in patients with proven acute intestinal ischemia were compared to patients with other diagnoses. RESULTS: Serum tumor necrosis factor-alpha levels were moderately increased in patients with acute intestinal ischemia compared to controls 96.9 +/- 98.9 pg/mL vs. 60.8 +/- 63.7 pg/mL, P = 0.16. Serum interleukin-6 levels were significantly increased in patients with acute intestinal ischemia, 15.778 +/- 21.349 pg/mL vs. 2.844 +/- 5.625 pg/mL, P = 0.01. CONCLUSIONS: Serum interleukin-6 levels may prove useful in diagnosing patients with acute intestinal ischemia.
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