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  • Title: Evaluation of the mutagenicity of antimalarial products isolated from Solanum nudum (Solanaceae).
    Author: Pabón A, Blair S, Carmona J, Zuleta M, Saez J.
    Journal: Pharmazie; 2003 Apr; 58(4):263-7. PubMed ID: 12749410.
    Abstract:
    Diosgenone is a major component of the hexane extract from the plant Solanum nudum (Solanaceae). The products from degraded and acetylated diosgenone that showed in vitro antimalarial activity against the FCB-2 strain of Plasmodium falciparum and methanol, dichloromethane and ethereal extracts of Solanum nudum were tested for their mutagenic activity using the Ames test with the TA-97a, TA-98, TA-100 and TA-102 strains of Salmonella typhimurium. These compounds were not mutagenic at the tested concentrations.
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