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  • Title: Human cord blood long-term engrafting cells are CD34+ CD38-.
    Author: Ishikawa F, Livingston AG, Minamiguchi H, Wingard JR, Ogawa M.
    Journal: Leukemia; 2003 May; 17(5):960-4. PubMed ID: 12750710.
    Abstract:
    There have been controversies about CD34 and CD38 expression by human cord blood (CB) stem cells. Using the newborn NOD/SCID/beta2-microglobulin-null mouse assay that we recently developed, we examined the in vivo engrafting capability of human CB cells. Almost all of the 4-5 months engrafting cells were found in CD34(+) population. The capability of secondary reconstitution was found only in the CD34(+) cells. When the CD34(+) CB cells were separated into CD38(-) and CD38(+) subpopulations and tested for engraftment, the majority of the engrafting cells were detected in the CD38(-) subpopulation. These findings are consistent with the results from studies of murine stem cells and strongly indicate that the phenotype of human CB stem cells is CD34(+) CD38(-).
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