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  • Title: Deep resting glabellar rhytides respond to BTX-A and Hylan B.
    Author: Carruthers J, Carruthers A, Maberley D.
    Journal: Dermatol Surg; 2003 May; 29(5):539-44. PubMed ID: 12752525.
    Abstract:
    BACKGROUND: BTX-A is the standard treatment for glabellar furrows. However, some individuals have resting glabellar rhytides that are sufficiently deep that they respond poorly to BTX-A alone. OBJECTIVE: To compare the efficacy of BTX-A combined with intradermal Hylan B with the efficacy of BTX-A alone in individuals with moderate to severe glabellar rhytides. METHODS: This was a retrospective study of 16 subjects with moderate to severe glabellar rhytides. Their response to Hylan B plus BTX-A was compared clinically and photographically to their response to BTX-A alone. RESULTS: All subjects had moderate or severe glabellar rhytides at rest before treatment. After BTX-A alone, none (0%) had achieved no or mild rhytides. After BTX-A and Hylan B injection, only 1 of 16 (6%) had moderate glabellar rhytides, with the remainder (94%) being mild. CONCLUSION: Moderate to severe glabellar rhytides were treated better by BTX-A combined with Hylan B injection than by BTX-A alone.
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