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  • Title: Transitional control in Semliki forest virus infected cells.
    Author: Käärläinen L, Lachmi BE, Glanville N.
    Journal: Ann Microbiol (Paris); 1976 Jan; 127A(1):197-203. PubMed ID: 1275398.
    Abstract:
    The cistron of the 42 S RNA, which codes for other than structural proteins, is poorly translated in the middle of the growth cycle. The translational control operating in the infected cells is not expressed in cell-free protein synthesising systems programmed with the 42 S RNA, since mostly non-structural proteins are made in vitro. One of our temperature-sensitive mutants of SFV, ts-1, directs the synthesis of two non-structural proteins with molecular weights of 78,000 (ns-78) and 86,000 (ns-86) but only at the restrictive temperature. This indicates that the synthesis of the non-structural proteins is controlled by viral rather than cellular factor(s). Temperature shift experiments revealed that the control mechanism was only slowly affected by the change of the temperature.
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