These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Powdered cellulose as excipient for extrusion-spheronization pellets of a cohesive hydrophobic drug.
    Author: Alvarez L, Concheiro A, Gómez-Amoza JL, Souto C, Martínez-Pacheco R.
    Journal: Eur J Pharm Biopharm; 2003 May; 55(3):291-5. PubMed ID: 12754003.
    Abstract:
    This study compared a powdered cellulose (PC) and a microcrystalline cellulose (MCC) as sole excipients in the preparation of furosemide pellets by extrusion-spheronization. Pellets prepared with PC and 25 or 50% furosemide showed smaller mean size, a broader particle size distribution, similar sphericity, greater surface roughness and higher friability than equivalent pellets prepared with MCC. Furosemide release rate was markedly higher from PC pellets, which may be attributable to their higher micropore volume.
    [Abstract] [Full Text] [Related] [New Search]