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  • Title: Lupus erythematosus-like syndrome with a familial deficiency of C2.
    Author: Douglass MC, Lamberg SI, Lorincz AL, Good RA, Day NK.
    Journal: Arch Dermatol; 1976 May; 112(5):671-4. PubMed ID: 1275522.
    Abstract:
    Several cases of isolated C2 deficiency in man have been reported in the medical literature. The earliest cases did not seem to be associated with known diseases or syndromes; more recently, reports of C2 deficiency associated with systemic lupus erythematosus; anaphylactoid purpura, recurrent infections, and dermatomyositis have appeared. We report here another case of C2 deficiency. The propositus, a 24-year-old woman, had a lupus erythematosus-like rash and a history of arthralgia, as well as a selective deficiency of C2. Studies of hemolytic C2 of the immediate members of her family indicate an autosomal-recessive mode of inheritance. These findings add to the increasing evidence that a C2 deficiency predisposes some persons to serious vascular diseases.
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