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  • Title: Charcot-Marie-Tooth disease and vincristine.
    Author: Orejana-García AM, Pascual-Huerta J, Pérez-Melero A.
    Journal: J Am Podiatr Med Assoc; 2003; 93(3):229-33. PubMed ID: 12756314.
    Abstract:
    This article reports on a case of sensorimotor neuropathy in a 55-year-old man that developed after vincristine therapy. Subsequent biopsy of the sural nerve and electromyographic studies revealed the presence of Charcot-Marie-Tooth disease. Only 17 patients who developed severe neuropathy with very low accumulated doses of vincristine have been described in the literature. Pain and lateral ankle instability were treated with a functional orthosis. Orthopedic treatment and the biomechanical basis of foot and ankle problems in patients with vincristine therapy-induced Charcot-Marie-Tooth disease are discussed.
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