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  • Title: The effect of carboxymethylcellulose on antiproteolytic activity of unmodified, guanidylated and acetylated BPTI.
    Author: Szopa J.
    Journal: Arch Immunol Ther Exp (Warsz); 1976; 24(2):305-13. PubMed ID: 1275667.
    Abstract:
    Acetylated BPTI loses its antitrypsin activity, but retains antichymotrypsin activity. Guanidylation diminishes the inhibitor's antitrypsin activity without affecting its antichymotrypsin activity. Acetylated inhibitor in complex with sodium salt of carboxymethylcellulose recovers antitrypsin activity which it did not have in the free state. Unmodified and guanidylated inhibitor in complex with CM-cellulose shows weaker antitrypsin as well as antichymotrypisn activity in comparison with free inhibitors.
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