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  • Title: Intranuclear Ca2+ signals within individual nuclear lobes of neutrophils.
    Author: Hodges R, Laffafian I, Hallett MB.
    Journal: Cell Biol Int; 2003; 27(5):395-402. PubMed ID: 12758086.
    Abstract:
    Cytosolic free Ca(2+)and intranuclear Ca(2+)behave similarly in human neutrophils. However, conventional laser scanning at 350 ms/frame resolution at lower than physiological temperatures demonstrates that (i) the nuclear fluo3-Ca(2+)signal persists longer than the cytosolic signal in some (but not all) nuclear lobes, (ii) the neutrophil nuclear membrane and fine inter-lobe filaments present barriers to diffusion of fluo3-Ca(2+)and lucifer yellow, and (iii) the diffusion barrier correlates with condensed chromosomal material on the nuclear envelope and blockage of the movement of fluo3-Ca(2+)into individual nuclear lobes.
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