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  • Title: [Preliminary study on relationship between different viral pathogenesis and disease prognosis in patients with severe viral hepatitis].
    Author: Lian Y, Wu W, Shi Y.
    Journal: Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi; 1999 Dec; 13(4):355-7. PubMed ID: 12759976.
    Abstract:
    OBJECTIVE: To study the relationship between different viral pathogenesis and disease prognosis in severe viral hepatitis. METHODS: Different viral pathogenesis of 87 dead and live cases with severe viral hepatitis were compared. RESULTS: Total mortality of 87 patients with severe hepatitis was 74.71% (65/87), total prevalence of HBV infection alone in these patients was 41.38% (36/87). The detection rates of HBV infection alone and superinfection of different hepatitis viruses in 68 patients with chronic severe hepatitis (CSH) were 41.18% (28/68) and 58.82% (40/68) respectively. The prevalences of superinfection of HBV and HEV or HAV and superinfection of HBV and CMV in patients with CSH were 27.94% (19/68) and 10.29 (7/68) respectively. The mortality of superinfection of HBV and CMV (85.71%) was the highest, followed by HBV infection alone (77.78%). In addition, the prevalence and mortality of HBV infection alone in 19 patients with acute or subacute severe hepatitis was the highest. CONCLUSION: HBV, HEV or HAV infection alone was the main viral pathogenesis of severe hepatitis. Superinfection of different viruses in patients with CSH was the most common viral infection type. An unpromising prognosis of superinfection of HBV and CMV in CSH is noted.
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