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  • Title: A therapy-resistant chronic leg ulcer treated successfully with topical basic fibroblast growth factor.
    Author: Kurokawa I, Hayami J, Kita Y.
    Journal: J Int Med Res; 2003; 31(2):149-51. PubMed ID: 12760319.
    Abstract:
    We report a patient with rheumatoid arthritis who had a chronic leg ulcer with long-standing resistance to therapy. Topical basic fibroblast growth factor (bFGF) at a dose of 30 micrograms/day for 3 months was clinically effective in reducing the ulcer area by promoting angiogenesis, re-epithelization, granulation and scar formation. bFGF may be an effective treatment for therapy-resistant leg ulcers.
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