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  • Title: D-penicillamine and plasmapheresis in acute liver failure secondary to Wilson's disease.
    Author: Rodríguez Fariña E, Tremosa Llurba G, Xiol Quingles X, Lores Obradors A, Castellote Alonso J, Gornals Soler JB, López Núñez C.
    Journal: Rev Esp Enferm Dig; 2003 Jan; 95(1):60-2, 63-5. PubMed ID: 12760731.
    Abstract:
    We report a case of a 19-year-old woman with acute liver failure, Coombś negative hemolytic anemia, and renal failure as initial manifestations of Wilsoń disease with recovery following medical treatment. The clinical picture and low serum transaminase and alkaline phosphatase levels gave us a clue to suspect Wilsoń disease and to initiate plasmapheresis and D-penicillamine soon after admission. The serum and urinary copper levels were elevated with low serum ceruloplasmin. We proceeded to ambulatory follow-up with medical treatment with D-penicillamine. A few months later, during the course of a laparoscopic cholecystectomy because of symptomatic gallstone disease, a liver biopsy sample was obtained that showed histological liver fibrosis and strongly elevated levels of liver tissue copper.
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