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  • Title: Nasal Rosai-Dorfman disease with intracranial involvement: a case report.
    Author: Chang YC, Tsai MH, Chen CL, Tsai CH, Lee AY.
    Journal: Am J Otolaryngol; 2003; 24(3):183-6. PubMed ID: 12761707.
    Abstract:
    Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) is a rare but distinctive entity. It was initially described as a nodal-based disease but later found to affect a variety of extranodal sites. The diagnosis of Rosai-Dorfman disease is based on the unique histologic changes that are characterized by proliferation of S-100 protein-positive histiocytes, the presence of emperipolesis, and a mixture of prominent lymphoplasmacytic infiltrates. The etiology of Rosai-Dorfman disease is unknown. It usually runs a benign clinic course and may resolve spontaneously, but cases running protracted courses have also been reported. We report an unusual case of recurrent extranodal Rosai-Dorfman disease in nasal and paranasal cavities with intracranial involvement surviving for more than 9 years.
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