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  • Title: The reactions of oxo-osmium ligand complexes with isopentenyl adenine and its nucleoside.
    Author: Ragazzo JA, Behrman EJ.
    Journal: Bioinorg Chem; 1976; 5(4):343-52. PubMed ID: 1276231.
    Abstract:
    We report syntheses of oxo-osmium(VI)bis(ligand) esters of N6-(delta2-isopentenyl) adenine (6-ipAde) and its nucleoside (IPA) which result from the addition of OsO4 to the double bond of the isopentenyl group. A study of the kinetics of these reactions shows that under typical conditions the rates of reaction relative to thymidine are as follows: for OsO4-pyridine: thymidine = 1; 6-ipAde = 4600: for OsO4-2,2'-bipyridyl: thymidine = 380; 6-ipAde = 8600; IPA = 8600. We also report syntheses of osmate esters of IPA in which the osmium is bonded through the 2'-and 3'-hydroxyl groups of the ribose residue.
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