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  • Title: Synthesis of griseolic acid analogues: regioselective alpha-facial [1,2]-migration in the rhodium acetate catalyzed reaction of D-glucose derived alpha-diazo-beta-keto ester.
    Author: Karche NP, Jachak SM, Dhavale DD.
    Journal: J Org Chem; 2003 May 30; 68(11):4531-4. PubMed ID: 12762763.
    Abstract:
    This paper describes an efficient route for the synthesis of known and novel griseolic acid analogues 1d and 1e, respectively. The key intermediate dioxabicyclo derivative 6, with the required stereochemical orientation at C6, was obtained by rhodium acetate catalyzed reaction of d-glucose derived alpha-diazo-beta-keto ester 5 in a novel high-yielding methodology.
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