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  • Title: New antimalarial bis-dehydroaporphine alkaloids from Polyalthia debilis.
    Author: Kanokmedhakul S, Kanokmedhakul K, Yodbuddee D, Phonkerd N.
    Journal: J Nat Prod; 2003 May; 66(5):616-9. PubMed ID: 12762793.
    Abstract:
    Four new dimeric aporphinoids named bidebilines A-D (1-4), bis-7,7'-dehydroanonaine (1), 7-dehydroanonaine-7'-dehydro-8'-methoxyanonaine (2), bis-7,7'-dehydro-8,8'-dimethoxyanonaine (3), and bis-7,7'-dehydro-10,10'-dimethoxyanonaine (4), were isolated from the roots of Polyalthia debilis. Their structures were established on the basis of spectral evidence. Compounds 3 and 4 exhibited moderate antimalarial activity with IC(50) values of 5.4 and 4.1 microg/mL, respectively.
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