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  • Title: Sterol and triterpenoid constituents of Verbena littoralis with NGF-potentiating activity.
    Author: Li Y, Ishibashi M, Satake M, Chen X, Oshima Y, Ohizumi Y.
    Journal: J Nat Prod; 2003 May; 66(5):696-8. PubMed ID: 12762811.
    Abstract:
    Two new sterols, stigmast-5-ene 3beta,4beta,7alpha,22alpha-tetraol (1) and stigmast-5-ene 3beta,7alpha,22alpha-triol (2), were isolated from the aerial parts of a Paraguayan medicinal plant, Verbena littoralis, together with the known compounds ursolic acid (3) and oleanolic acid (4). The structures of 1 and 2 were elucidated by spectroscopic analyses. Compounds 2-4 showed an enhancing activity of nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells.
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