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  • Title: The thermogenic function of the sarcoplasmic reticulum Ca2+-ATPase of normal and hyperthyroid rabbit.
    Author: de Meis L, Arruda AP, da-Silva WS, Reis M, Carvalho DP.
    Journal: Ann N Y Acad Sci; 2003 Apr; 986():481-8. PubMed ID: 12763868.
    Abstract:
    After formation of a Ca(2+) gradient, the amount of heat released during the hydrolysis of each mol of ATP cleaved (DeltaH(cal)) varies depending on the Ca(2+)-ATPase isoform expressed by the muscle cell. In vesicles derived from the sarcoplasmic reticulum of white muscle (SERCA 1) most of the ATP cleaved is not coupled to Ca(2+) transport, and the DeltaH(cal) varies between -20 and -22 kcal/mol. In contrast, in vesicles derived from red muscle (SERCA 2a) the hydrolysis of ATP is coupled with Ca(2+) transport, and the DeltaH(cal) varies between -12 and -14 kcal/mol. Hyperthyroidism increases the rate of heat production by the Ca(2+)-ATPase fourfold in white muscle and 40-fold in red muscle. In hyperthyroid rabbits, the amount of sarcoplasmic reticulum protein recovered from white and red muscle is four- to fivefold greater than that obtained from control rabbits. Hyperthyroid red muscle expresses SERCA 1, and the vesicles derived from these muscle hydrolyze ATP through a catalytic route that is not coupled to Ca(2+) transport, thus increasing the amount of heat released during ATP hydrolysis, the DeltaH(cal) varying between -20 and -22 kcal/mol.
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