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  • Title: [Differences in furosemide-induced changes of summating potential and endocochlear potential in guinea pigs].
    Author: Hu N, Jiang W, Wang L.
    Journal: Zhonghua Er Bi Yan Hou Ke Za Zhi; 1999 Oct; 34(5):282-5. PubMed ID: 12764825.
    Abstract:
    OBJECTIVE: To investigate the physiological properties of summating potential (SP) and to compare the different changes between SP and endocochlear potential (EP) induced by Furosemide in guinea pigs. METHODS: SP in response to clicks with alternative polarities at 105 dB peSPL was recorded from a electrode in the facial nerve canal. EP was measured with a glass microelectrode in the basal turn of the cochlea. SP and EP were observed simultaneously and continuously after injection of Furosemide or the solution of Furosemide-bovine serum albumin injected into the jugular vein of the animal. RESULTS: Before furosemide application, only SP could be recorded with small or without +SP. After furosemide injection, EP declined dramatically followed by reduction of the -SP which quickly vanished, while +SP appeared or the amplitude increased. When EP recovered to a certain level, +SP disappeared or dramatically decreased and then -SP reappeared. The amplitude of -SP increased progressively with EP recovery. Both -SP and EP recovered to the pre-injected level in 60 min after the furosemide application. CONCLUSION: The results suggest that Furosemide induced distinct changes of -SP and +SP, the two components of SP. The changes of -SP amplitude was consistent with that of the EP value, while the changes of +SP amplitude were contrary to that of the EP value.
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