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  • Title: [The effects of substance P antibody on tuning curve of auditory evoked potential of cochlear nucleus and inferior colliculus in guinea pigs].
    Author: Guo M, Wang J.
    Journal: Zhonghua Er Bi Yan Hou Ke Za Zhi; 1999 Apr; 34(2):70-3. PubMed ID: 12764850.
    Abstract:
    OBJECTIVE: To explore the effects of substance P on the frequency analysis of sound signals in the auditory brainstem. METHODS: The electrodes were implanted into the cochlear nucleus (CN) and the inferior colliculus (IC) of guinea pigs. The auditory evoked potential in CN (CN-AEP) and IC (IC-AEP) was recorded with tone pip stimulation and tone burst forward masking techniques. The Q10 dB values of the tuning curves were compared between the CN-AEP and IC-AEP after injection of SP antibody or rabbit serum with the same dosage (used as control) into the nucleus. RESULTS: After injection of SP antibody, the Q10 dB values of the tuning curves of CN-AEP and IC-AEP had no significant changes in 1 kHz and 2 kHz probe tone groups. When probe tone frequencies were 4 kHz and 6 kHz, there was a significant difference between the two frequency groups in Q10 dB. In addition, the higher frequency slope and lower frequency slope value had corresponding changes. CONCLUSION: The results imply that SP could act as a neuromediator in the auditory afferent system and participated in the high frequency analysis in the auditory brainstem.
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