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  • Title: [Study on the association between squamous cell carcinoma of larynx and HPV subgene by PCR].
    Author: Wang L, Zhang T, Zhang F.
    Journal: Zhonghua Er Bi Yan Hou Ke Za Zhi; 1999 Apr; 34(2):106-7. PubMed ID: 12764861.
    Abstract:
    OBJECTIVE: To measure the human papilloma virus(HPV) HPV-E1 in squamous cell carcinoma of larynx. METHODS: Polymerase chain reaction(PCR) was used to detect the HPV subgene in 25 specimens of laryngeal carcinoma and 6 normal larynges. RESULTS: Positive expression of HPV-E1 was detected in 17 of 25 cases(68%) with squamous cell carcinoma and all the recurrent cases. However, there was no positive expression of HPV-E1 in the normal larynges (P < 0.01). The expression rate was not significantly different among the histological grad groups. CONCLUSION: HPV-E1 infection was found in laryngeal carcinoma but not related to its histologic grading.
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