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  • Title: The effect of aspirin on 5-hydroxytryptamine uptake and release by human platelets.
    Author: Rendu F.
    Journal: Br J Pharmacol; 1976 May; 57(1):149-51. PubMed ID: 1276534.
    Abstract:
    The influence of aspirin on 5-hydroxytryptamine (5-HT) uptake and storage by human blood platelets has been investigated. Uptake of 5-HT was strongly inhibited. In 30 min aspirin released 50% of the 5-HT that had been incorporated into the platelets prior to the addition of the aspirin. These results are discussed in terms of possible interference with a 5-HT membrane receptor and the impairment of 5-HT storage in the dense granules.
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