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  • Title: Uptake of sialic acid by human erythrocyte. Characterization of a transport system.
    Author: Bulai T, Bratosin D, Artenie V, Montreuil J.
    Journal: Biochimie; 2003; 85(1-2):241-4. PubMed ID: 12765793.
    Abstract:
    Upon incubation of human red blood cells (RBC) with [4-9-14C] N-acetylneuraminic acid, the cells incorporated this sugar, as demonstrated by the identification of labelled N-acetylmannosamine in the cytosol, as a result of the action of the sialic acid pyruvate-lyase we discovered previously (Biochimie 84 (2002) 655). The mechanism is saturable and indicates the presence of a limited number of transporter molecules in the RBC membrane. This transport process may have relevance to the desialylation of membrane glycoconjugates which occurs during ageing of erythrocytes.
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