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  • Title: Mucormycosis (zygomycosis) in a heart-kidney transplant recipient: recovery after posaconazole therapy.
    Author: Tobón AM, Arango M, Fernández D, Restrepo A.
    Journal: Clin Infect Dis; 2003 Jun 01; 36(11):1488-91. PubMed ID: 12766845.
    Abstract:
    We describe the case of a diabetic patient who developed a severe invasive fungal infection due to Rhizopus species postoperatively after a dual heart/kidney transplantation with subsequent intensive immunosuppressive therapy. No improvement was noted with amphotericin B (deoxycholate) therapy, but salvage treatment with the new azole antifungal posaconazole (200 mg orally 4 times daily) resulted in dramatic clinical improvement as early as 1 week after the initiation of therapy that continued through 23 weeks of treatment, with marked clinical, mycological, and radiological improvements and no adverse events.
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