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  • Title: [Role of P53, nm23 proteins and vascular endothelial growth factor in angiogenesis and metastasis of laryngeal cancer].
    Author: Cheng W, Li X, Quan C, Guo X.
    Journal: Zhonghua Er Bi Yan Hou Ke Za Zhi; 2000 Apr; 35(2):147-9. PubMed ID: 12768677.
    Abstract:
    OBJECTIVE: To elucidate the role of P53, nm23 proteins and vascular endothelial growth factor (VEGF) on angiogenesis and metastasis of laryngeal cancer. METHODS: Specimens of 42 laryngeal carcinomas were studied by immunohistochemical staining for P53 protein, nm23 protein, VEGF and CD34 antibody. RESULTS: Positive expressions of P53 protein, nm23 protein and VEGF were found in 47.6%, 57.1% and 71.42% of laryngeal cancer specimens respectively. There was a positive relationship between P53 and VEGF expression. The microvessel density (MVD) in P53- or VEGF--positive tumors was significantly higher in patients with cervical lymph node metastases than those without metastases. No correlation was identified between nm23 and VEGF staining. The MVD in nm23-negative and VEGF--positive tumors was significantly high. These phenomena were more easily found in patients with cervical lymph node metastases than in patients without metastases. CONCLUSION: P53 gene play roles in the metastasis of laryngeal cancer through regulating VEGF expression and reacting MVD in tumor; and nm23 gene reacts through approaches other than regulating VEGF expression.
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