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  • Title: [The study of human papilloma viruses infection in juvenile pharynlaryngeal papillomatosis by PCR and dot blot hybridization].
    Author: Chen B, Bao Q, Zhang H.
    Journal: Zhonghua Er Bi Yan Hou Ke Za Zhi; 2000 Aug; 35(4):286-8. PubMed ID: 12768707.
    Abstract:
    OBJECTIVE: To study the relationship between infection of human papillomavirus and juvenile pharynlaryngeal papilloma. METHODS: Polymerase chain reaction (PCR) and dot blot hybridization were used to detect HPV6,11,16,18,33 DNA of 35 samples of pharynlaryngeal papilloma and 10 samples of vocal nodule. RESULTS: The positive rate of HPV in pharynlaryngeal papilloma was 91.4% (30/35). Among them the positive rates of HPV6 and HPV11 were 54.2%(19/35) and 25.7%(9/35), the positive rate of multiple types of HPV6 + 11 was 11.4%(4/35). The positive rate of HPV16,18,33 was negative. The positive rate of HPV in vocal nodule was negative and were significantly different from that of the pharynlaryngeal papilloma group. CONCLUSION: The results suggest that infection with HPV, especially with HPV6, is closely associated with the development of juvenile pharynlaryngeal papilloma in Wenzhou area. HPV-DNA detected by PCR and dot blot hybridization has highly specificity and sensitivity.
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