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  • Title: [T-lymphocyte subsets and inflammatory cytokines of interleukin-5 and interleukin-10 expression in human nasal polyp tissue].
    Author: Yuan X, Yu D, Yu Y.
    Journal: Zhonghua Er Bi Yan Hou Ke Za Zhi; 2000 Oct; 35(5):363-6. PubMed ID: 12768738.
    Abstract:
    OBJECTIVE: To investigate the distribution of T-lymphocyte subsets (CD4+ and CD8+ cells) and the expression of IL-5 and IL-10 protein-positive cells in nasal polyps. METHODS: The specimens of thirty-two nasal polyps and six control subjects were studied by Immunohistochemical method to detect CD4+, CD8+, IL-5+ and IL-10+ cells. A mean numbers of positive cells per high power field (10 x 40) were counted. All data were analyzed with t-test and correl-test. RESULTS: There were significantly large number of CD4+ and CD8+ cells in nasal polyps (P < 0.001). A significant predominance of CD4+ cells over CD8+ cells was found in the two subgroups (subepithelia, arounding glands and blood vessels) of nasal polyp (P < 0.001). There were an abundant number of IL-5+ IL-10+ cells, whereas significantly difference higher concentrations than that in the controls (P < 0.001). IL-5+ cells were more than IL-10+ cells in nasal polyps (P < 0.05), and most of IL-5+ cells were plasmacytes and lymphocytes. There was a significant correlation between the counts of CD4+/CD8+ and IL-5+/IL-10+ in the subgroup of nasal polyps arounding glands and blood vessels (r = 0.78, P < 0.01). CONCLUSIONS: This study indicated that CD4+ T-lymphocytes and IL-5 high expression may play an important role in the nasal polyps. Migration of plasmacytes and lymphocytes in polyps may participate in the inflammatory reaction. The disturbance of cellular and humoral immunity and imbalance of cytokines distribution may play a crucial role in the pathogenesis of nasal polyps.
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