These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of vincristine on sister chromatid exchanges of normal human lymphocytes.
    Author: Stoll C, Borgaonkar DS, Levy JM.
    Journal: Cancer Res; 1976 Aug; 36(8):2710-3. PubMed ID: 1277180.
    Abstract:
    In vitro analysis of the mitosis from 3-day lymphocyte cultures from two normal males and two normal females treated with bromodeoxyuridine and stained with acridine orange after addition of vincristine during different times demonstrated that vincristine inhibits the progression of the second division. When the second division progressed, the number of sister chromatid exchanges was significantly decreased. Vincristine could act by inhibiting the copying of DNA. A dosage effect is demonstrated when vincristine is added to the cultures during the first 24 hr.
    [Abstract] [Full Text] [Related] [New Search]