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  • Title: Low-grade malignant eccrine spiradenoma with systemic metastases.
    Author: Leonard N, Smith D, McNamara P.
    Journal: Am J Dermatopathol; 2003 Jun; 25(3):253-5. PubMed ID: 12775989.
    Abstract:
    Malignant eccrine spiradenoma (MES) is a very rare tumor. Tumors can be low grade or high grade. There are nine cases in the literature with systemic metastases. Of these, only one was low grade; the others had obvious features of high-grade malignancy such as pleomorphism, increased mitoses, and abnormal mitoses. Low grade MESs are more difficult to diagnose and are said to have a better prognosis. We report an additional case of low-grade MES with systemic metastases. It had a monotonous appearance with few mitotic figures and minimal pleomorphism. Vascular invasion was seen in both cases of low-grade MES and may be an important prognostic feature.
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