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  • Title: [Dynamics of some carbohydrate metabolic indices in the liver and the alcohol concentration in it depending on the time of day of its administration].
    Author: Gubin GD, Latenkov VP, Zhuravleva TD, Zaroastrov OM.
    Journal: Farmakol Toksikol; 1976; 39(2):233-6. PubMed ID: 1278359.
    Abstract:
    The liver glycogen and sugar levels in intact rats are shown to experience diuranal variations with a maximum at 3-9 and minimum at 15-21 hours. Intragastric administration of ethanol in a dose of 1.5 ml/100 g produced an abrupt fall of the glycogen content in the liver of rats in 3.12 and maximally after a lapse of 6 hours, this being followed by a drop in the amount of sugar in 12 hours. The decline in the level of metabolites at different periods of the day (3, 9, 15 and 21 hr) was dissimilar. The lethality among the animals and concentration of the alcohol in the liver 3 and 6 hours following the action of alcohol at the hours of the day under study correlated and were inversely proportional to the sugar and glycogen content of the same hours of the day.
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