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  • Title: Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock.
    Author: Bessho Y, Hirata H, Masamizu Y, Kageyama R.
    Journal: Genes Dev; 2003 Jun 15; 17(12):1451-6. PubMed ID: 12783854.
    Abstract:
    Hes7, a bHLH gene essential for somitogenesis, displays cyclic expression of mRNA in the presomitic mesoderm (PSM). Here, we show that Hes7 protein is also expressed in a dynamic manner, which depends on proteasome-mediated degradation. Spatial comparison revealed that Hes7 and Lunatic fringe (Lfng) transcription occurs in the Hes7 protein-negative domains. Furthermore, Hes7 and Lfng transcription is constitutively up-regulated in the absence of Hes7 protein and down-regulated by stabilization of Hes7 protein. Thus, periodic repression by Hes7 protein is critical for the cyclic transcription of Hes7 and Lfng, and this negative feedback represents a molecular basis for the segmentation clock.
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